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One of the greatest current challenges is to identify markers for prodromal disease stages, which would allow novel disease-modifying therapies to be started earlier

In this regard, it has been demonstrated that downregulating miR-145 increases the expression of genes linked to pluripotency, including POU5F1 and SOX2, which improves the rates at which blastocysts develop [267]

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Oxalate excretion results from endogenous catabolism of hydroxyproline, uracil, orotic and ascorbic acids, and oxalate can originate from dietary sources
