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[63], after 4 weeks of MNA administration (100 mg/kg), no significant differences were found between MNA-treated and untreated diabetic db/db mice with regard to the levels of fasting blood glucose and HbA1c and the body weights of the MNA-treated db/db mice did not decrease but tended to increase compared to those of the untreated db/db mice

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Limitations of Use: DDAVP Nasal Spray is not indicated for: Treatment of nephrogenic diabetes insipidus, Treatment of primary nocturnal enuresis [see Warnings and Precautions (5.1)], Use in patients with conditions that compromise the intranasal route of administration (e.g., severe nasal congestion and blockage, nasal mucosa atrophy, severe atrophic rhinitis, recent nasal surgery such as transsphenoidal hypophysectomy) [see Warnings and Precautions (5.2)]

This slowly becomes a weekly interval for a month before it becomes once a month