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Since there is little knowledge of how efficiently the peptide crosses the blood brain barrier when administered parenterally, an intranasal delivery route was selected for this study

Cagrilintide takes that natural mechanism and extends it dramatically

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Minori Koga for experimental support and discussions

We used a unique chemistry approach to tune the reactivity of our molecule, so that were targeting what would typically be considered a bad biomarker. The researchers tuned the dynamic range of the molecule so that it would not react to glutathione under healthy conditions but would react with the excess glutathione made by cancer cells

The washout period refers to the time from the last administered dose to the time of the start of the in-competition period