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LDH cytotoxicity assay was performed as previously described ( 3 cells per well in 96-well plates

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Consistent with our previous findings 5 , cystine starvation promoted the rapid depletion of cellular cysteine (Fig

SAM and NAD + serve as critical cofactors in cellular energy metabolism and redox states ( + levels, resulting in the upregulation of polyamine flux activation and increased energy expenditure ( FIGURE 2 3.2 NNMT and diabetes Diabetes is caused by a fundamental disturbance in the metabolism of glucose and is characterised by IGT, elevated fasting blood glucose, and inadequate insulin secretion or IR (Tripathi and Srivastava, 2006