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Important safety considerations include avoidance of tyramine-rich foods to prevent hypertensive crisis and avoidance of concomitant serotonergic medications (e.g., SSRIs and SNRIs) to reduce the risk of serotonin syndrome

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The results revealed that the combination of (-)-Vestitol and Salviolone regulated a greater number of genes in APP/PS1 transgenic mice than either natural product alone (Fig