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Brain Research Reviews 26 (23): 113135

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Heres a general guideline on how often B12 shots are administered: For Severe Deficiency : Initially, B12 shots may be given daily or weekly to rapidly boost levels in someone who has a significant deficiency

Subcutaneous is the most common method, with most protocols at 250 to 500 mcg per injection

This might sound high compared to the NIH's Recommended Dietary Allowance of just 2.4 mcg daily for adults, but don't worry the injection method allows for safe delivery of these higher doses, and B12 is water-soluble, meaning your body efficiently eliminates any excess