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Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling

1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice

doi: 10.4103/1673-5374.293145

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The result can include increased oxidative stress, inflammation, and cellular damage

Each peptide has different effective dosing thresholds