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EG exposure in this study resulted in high serum magnesium levels, suggesting depletion of intracellular electrolyte concentrations, which can impair enzyme activity, protein synthesis, energy metabolism, and detoxification mechanisms, and endanger proper kidney function

Long-term consumption of food-derived chlorogenic acid protects mice against acetaminophen-induced hepatotoxicity via promoting PINK1-dependent mitophagy and inhibiting apoptosis

Eur J Med Chem 2023;259:115688

Overall, the use of mixed models with interaction terms enhanced the reliability and generalizability of the findings in this longitudinal analysis, offering a comprehensive view of the factors influencing treatment outcomes over time