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doi: 10.1186/s12920-023-01666-w 248 RiveraCAWheelerMDEnomotoNThurmanRG

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moreover, l-ARG has been found to play a relevant positive impact on atherosclerosis, as demonstrated by two RCTs showing that administration of l-ARG improved endothelium-dependent vasodilation of brachial [55] and coronary arteries [56] in patients with angiographically reported coronary artery disease

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Concretely, enhanced glycolysis in PCa cells leads to HIF-1 lactylation, upregulating KIAA1199, accompanied by increased secretion of VEGFA, ultimately advancing angiogenesis and vasculogenic mimicry