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Yet that tiny change shifts the peptide behavior in meaningful ways

We assume the value of E Cl to be such that Cl concentration is at equilibrium, that is the Cl synaptic influx and extrusion through KCC2 cancel each other out, this yields where V mean is the time averaged value the membrane potential taken to be V mean = 60 mV

This is important for their treatment

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Animals were given equivalent amounts of cuprizone, regardless of feed formulation