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Description
The pharmacokinetic parameters assessed after multiple doses on Day 6 and Day 7 were: C max at steady state ( C max,ss ), t max at steady state ( t max,ss ), minimum concentration at steady state ( C min,ss ), AUC 0t at steady state (AUC 0t,ss ), AUC during the interval at steady state (AUC ,ss , calculated using the trapezoidal method), average concentration at steady state ( C ave,ss , calculated as AUC t,ss / t ), accumulation ratio (ARAUC, calculated as AUC ,ss /AUC 012 ) and peaktrough fluctuation [PTF, calculated as ( C max,ss C min,ss )/ C ave,ss 100)] of NAC in plasma, and Ae 0t at steady state (Ae 0t,ss ) of NAC in urine

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ALF Due to Viral Hepatitis The incidence of viral-induced ALF has changed significantly over the last decade

doi: 10.1128/jb.161.1.438-441.1985

However, some studies suggest that vitamin E treatment may increase risks of all-cause mortality and hemorrhagic stroke, though conflicting results make these studies inconclusive [72,81]
