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For the most part, the RGS proteins are promiscuous in their ability to deactivate G-proteins, while which RGS is involved in a given signaling pathway seems more determined by the tissue and GPCR involved than anything else

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Start: Begin at 5 mg (50 units) once daily for Weeks 12 to gauge tolerability

However, in modern times, you can easily get it via a supplement or multivitamin