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"L-Glutathione helps brighten the skin by enhancing pheomelanin synthesis

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Metabolomics enrichment indicated that SAC modulates the glutathione metabolism pathway by regulating GSH levels, thereby influencing GPX4 stability and activity

Here, we profile key ferroptotic defence strategies including iron regulation, phospholipid modulation and enzymes and metabolite systems: glutathione reductase (GR), Ferroptosis suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Dihydrofolate reductase (DHFR), retinal reductases and retinal dehydrogenases (RDH) and thioredoxin reductases (TR)