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Grains of Paradise (Aframomum melegueta) is a West African spice in the ginger family that has been used in traditional medicine for centuries and studied clinically for its metabolic effects in the modern era. The mechanism of 6-paradol's thermogenic activity is activation of brown adipose tissue (BAT)

Thus a decrease in steady-state ATP level would suggest the breakdown of ATP producing machinery such as complex V

Many athletes combine it with structured performance support such as protein with creatine to optimize strength and recovery results

Clinical research is limited long term

Lysosomes fuse with the endocytic vesicles, and the chylomicron remnants are degraded by lysosomal enzymes

J Appl Physiol (2022) 132(3):86273