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Reported adverse effects were mild, including localized itching and burning [150]

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Overall, AOD-9604 appears safe, with a profile similar to a placebo

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A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig

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