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Intriguingly, a significant increase in total and selenium-dependent GPx ratios was observed ( P = 0.0099 and P = 0.0096, respectively) (Figures 6D and E), indicating an adaptive upregulation to mitigate oxidative damage, while the non-selenium-dependent GPx ratio remained stable (Figure 6F)

Lower-dose maintenance and full discontinuation produce different outcomes

The causal relationship of mitochondria, the most important organelle for energy metabolism in cardiomyocytes, with iron metabolism and ferroptosis in DCM has been scarcely investigated

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Among these, Vitamin D deficiency appears to be particularly prevalent

This interaction results in the production of neuropeptides, gut hormones, neurotransmitters, and microbe-associated molecular patterns (MAMPs)
