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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
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There is a second layer worth untangling: NAD+ itself versus NAD precursors
doi: 10.1038/nri3198, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 99
The azotemia progressed to IRIS AKI Grade 3 by Day 91 and became severe during the terminal stage of the disease (Day 112), with a BUN of 83 mg/dL (reference range, 1636 mg/dL) and creatinine of 5.0 mg/dL (reference range, 0.82.4 mg/dL)
Prior Phase 1 research involving ATH-1017 found it to be well tolerated
