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The rapid development of nanotechnology in recent years has enabled the widespread exploration of nanomaterials exceptional light, ultrasound, magnetic, and other stimulus-responsive properties, not only making it possible for CDT to synergize with other treatment methods in cancer therapy but also demonstrating superior anti-cancer activity compared to single treatments (125, 126)

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Notably, both DFO and ammonium ferric citrate enhance erastin-induced cell death, implying that although systemic iron overload exists in FRDA, cytosolic iron may still be limiting, and iron metabolism is dysregulated, contributing to cellular vulnerability

doi: 10.1371/journal.pone.0227377

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Proc Natl Acad Sci USA (2019) 116(34):168238