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[9] further studies have identified that meldonium is a substrate for gamma-butyrobetaine dioxygenase

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An increased risk of seizures in alcoholics with a history of multiple detoxifications is of clinical significance since poorer prognosis and a higher mortality rate have been reported for patients presenting with alcohol withdrawal-related seizures in contrast to individuals with seizures of unknown etiology (Pieninkeroinen et al., 1992)