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This distinctive type of cell death, reliant on iron-mediated phospholipid peroxidation (Wang et al., 2023), is intricately regulated by various cellular metabolic processes involving redox balance, iron homeostasis, mitochondrial function, as well as the metabolism of amino acids, lipids, and sugars, along with multiple associated signaling pathways relating to disease progression (Jiang X

& Zhou, F

By increasing ROS production and impairing antioxidant defenses, CB1 activation can aggravate oxidative damage

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Journal of agricultural and food chemistry 2016, 64 (5), 11031110

Luteolin and apigenin attenuate LPS-induced astrocyte activation and cytokine production by targeting MAPK, STAT3, and NF-B signaling pathways