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Notably, the enzyme has been linked to obesity and type 2 diabetes (T2D)

Both compounds require precise weekly dosing rather than daily administration

They experienced improved oocyte maturity compared to those with deficiencies
J.ZhangY.ThijssenV.BuijsN.GaoY.MateuszukL.et al (2021)
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The stimulation of hypothalamic POMC neurons is inhibited by -endorphin as an opioid reward process is involved in the short-term control of eating [239]

The 2026 broader peptide-therapy reviews (PMID 41966639) place this compound class in the wider research-context of unapproved compounds under active investigation
