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ACOG Committee on Practice Bulletins-Gynecology

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: An open-labelled randomized controlled trial
On one hand, it suppresses HMGB1 release and blocks the downstream TLR4 cascade, thereby reducing the production of inflammatory cytokines (40)

Zhang, A

In terms of epigenetics [161], methylation mediated by SAM increases ferroptosis in rheumatoid arthritis by enhancing the GPX4 promoter in response to glycine

doi: 10.7150/ijbs.91519 145 QiaoYLiJYuhCKoFMercuriLGAlkhudariJet al
