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The resolution of this debate likely hinges on technical advancements that allow direct, compartment-specific measurement of metabolic fluxes and oxygen dynamics in the tissue parenchyma

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By inactivating the STAT3 pathway, high concentrations of lycosin-I induce apoptosis in PCa cells (Shen et al., 2018)

Moreover, as non-thiol antioxidants (vitamins C and E) did not antagonize BSO+L-PAM cytotoxicity, it is likely that NAC and STS act to directly replace GSH as an absorbent of the highly reactive L-PAM

Xie L, Vance T, Kim B, Lee SG, Caceres C, Wang Y