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Conversely, inconsistent subcutaneous delivery might make a dose seem less effective than it actually is, potentially leading to premature dose increases

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Users stopping vitamin C serums generally report gradual benefit decline over 2-4 months with antioxidant protection loss occurring quickly (days to weeks), skin brightness fading over 1-2 months returning toward baseline, and collagen-related firmness improvements showing variable persistence with 30-50% benefit retention long-term for consistent users

doi: 10.1136/bmjgast-2019-000325

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None will shift from NICE guidelines