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Epidemiological evidence highlights their profound impact on global health, with CVD responsible for approximately 7.4 million and 6.7 million deaths annually, in addition to substantial morbidity, disability, and diminished quality of life (Hajar, 2016

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As discussed in detail below, identification of cognate receptors for various components of oxLDL and other oxidized lipoproteins has provided important insight into the mechanisms by which these oxidized lipoproteins exert their pathophysiological effects