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doi: 10.1016/j.micpath.2018.08.036

More so, direct extrapolation of these findings may be difficult due to physiological differences between rodent and humans

These include inflammation, energy failure, loss of cellular homeostasis, acidosis, elevated intracellular calcium levels, excitotoxicity, cytokine- and free radical-mediated cytotoxicity, complement system activation, disruption of the blood-brain barrier, activation of glial cells, oxidative stress, and leukocyte infiltration (Figure 1) (Kuriakose and Xiao, 2020)

Rigutto, C

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Makhlouf, A