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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

Low lean muscle mass: Tesamorelins growth hormone stimulation supports muscle preservation and growth alongside fat reduction, making it useful for patients who are losing both

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Stability implications Research indicates that semaglutide reconstituted with bacteriostatic water maintains stability for 28 days when refrigerated at 2-8 degrees Celsius

However, practical experience suggests both approaches produce beneficial outcomes, with the choice often driven by convenience rather than optimization concerns

doi: 10.1016/j.iotech.2022.100070 66 StortiPVescoviniRCostaFMarchicaVToscaniDDalla PalmaBet al