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Why most acute stroke studies are positive in animals but not in patients: a systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents

Coskun P, Helguera P, Nemati Z, Bohannan RC, Thomas J, Samuel SE, Argueta J, Doran E, Wallace DC, Lott IT, Busciglio J

9 Otherwise, the treatment of choice is use of a specific antidote, N-acetylcysteine, which reduces the hepatotoxic effects of acetaminophen overdose by replenishing glutathione stores, thereby enhancing production of the nontoxic metabolites

doi: 10.3390/ijerph17145089 23 NaherZBiswasSMollahFAliMArslanM

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