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Furthermore, T is the major lipid-soluble antioxidant in human plasma ( Reference Burton, Joyce and Ingold 9 ) and may (thereby) modulate gene expression and cellular signalling ( Reference Azzi, Gysin and Kempna 10 Reference Frank, de Pascual Teresa and Rimbach 12 )

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Beyond scavenging, it functions as a cofactor for GPx, chelates metal ions, and assists in regenerating vitamins C and E [31]

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It was found that both Grx2 overexpression and deletion shifted the equilibrium of Mia40 towards its reduced state, and decreased the rate of oxidative protein import and folding [176]

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