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One well-documented interaction involves the atypical antipsychotic clozapine: high-dose glycine supplementation has been reported to interfere with clozapines therapeutic efficacy in schizophrenia patients

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Semin Liver Dis 1998;18(4):389401

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Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1