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Senescent Cells in Skeletal Muscle: Implications for Muscle Regeneration

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However, frequent dosing of senolytics may increase the risk of adverse effects, making it essential to find the right balance between efficacy and safety.36 Emerging clinical and preclinical evidence suggests that intermittent senolytic dosing may reduce the risk of cumulative toxicity, including thrombocytopenia observed with agents such as navitoclax, while preserving efficacy.36 Continuous dosing, while potentially providing sustained clearance, increases exposure-related risks

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These results are consistent with previous studies that reported similar histological damage induced by MTX (Abdelaziz et al