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Of note, this review is focused on pulmonary toxicity

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Features of Gut Microbiota and Short-Chain Fatty Acids in Patients with First-Episode Depression and Their Relationship with the Clinical Symptoms

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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

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Another important neural circuit is the dopaminergic system

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Metabolic levels associated with MTX resistance In addition to the association between metabolic fold change and MTX resistance, we searched for correlations between metabolic concentration and resistance to MTX (expressed as IC50) at 48 and 96 hours in either the presence or absence of the drug ( Table 1 )

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