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The mainstream methods of cancer therapy have failed to address this issue, except for gene therapy, which has been shown to have some positive effects on cancer relapse [46]

24, 77717778.10.1523/JNEUROSCI.1842-04.2004 57 TufikS.Santos-SilvaR.TaddeiJ

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doi: 10.3389/fimmu.2025.1578940 Received 18 February 2025 Accepted 24 March 2025 Published 10 April 2025 Volume 16 - 2025 Edited by Fabrizio Fontana, University of Milan, Italy Reviewed by Bjrn Steen Sklhegg, University of Oslo, Norway Josephine Anthony, Meenakshi Academy of Higher Education and Research, India Updates Copyright 2025 Fang, Gao, Jiang, Li and Li

With respect to DNA damage, it has been shown that iodine oxidizes 2-deoxy-8-oxoguanosine [164] and 8-oxo-7,8-dihydroguanine [165], both resulting from oxidative damage to guanine bases