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Therefore, these medications can cause very similar side effects

In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited

The goal is to isolate which variables drive which outcomes

Japanese clinical practice guideline for diabetes 2019

Prescription drugs are intended to be used exactly as directed

Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency