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Article: How Often Should I Get B12 Shots

Preventative or Therapeutic Use : For those using B12 injections for reasons other than a severe deficiencylike to enhance energy, mood, or for overall well-beingthe shots might be administered less frequently, such as monthly or even bimonthly

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Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies