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Iron overload following ischemia may be mediated through two primary pathways: IL-6JAK/STAT3hepcidin axis: Ischemia-induced IL-6 activates the JAK/STAT3 signaling pathway, which enhances hepcidin expression

JCYJ20220818102201003, KCXFZ20230731094500001, and JCYJ20220818102201002), and the Guangdong Basic and Applied Basic Research Foundation (Grant No

Mahgoub et al., 2020), anti-tumor (Yu et al., 2015

Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell

118 , e2105482118 (2021)

This heightened expression has been observed to result in a substantial reduction in patient survival, a phenomenon that is attributed to the enzymes capacity to enhance glutamine metabolism within cancerous cells
