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CTCs show significantly increased tumorigenicity and metastatic potential in a novel orthotopic syngeneic model of metastatic cancer [52]

Indeed, such an approach disregards the diversity of the underlying disease mechanisms, clinical heterogeneity, and dynamic progression of each disease subset

( j ) Levels of dihydroorotate (DHO), aspartate, or the NAD/NADH ratio in SEM and NALM6 cells after 8 days of treatment with BCS and/or inosine and uridine (Ino/Urid) relative to vehicle treated cells