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Pattern recognition receptor (PRR)-dependent pathway: cholesterol-rich microdomains exposed on the crystal surface directly bind to Toll-like receptors 2/4 (TLR2/4), thereby initiating the MyD88 signaling cascade (Narang and Dalbeth, 2020)

Other supportive evidence is the correlation of the rate of transport of a given substance with transcellular electrical resistance, in which lower transport rates of substances assumed to be transported paracellularly are observed in high-resistance, tight epithelia, although electrical resistance and the transport of marker molecules do not always coincide

These studies suggested GSTM2 regulated lipid metabolism specially beyond detoxification/antioxidant, the basic functions of GSTs

Int J Mol Sci 14:74057432 Zechmann B, Mauch F, Sticher L, Muller M (2008) Subcellular immunocytochemical analysis detects the highest concentrations of glutathione in mitochondria and not in plastids

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