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Preclinical evidence Mice with a deletion of the 22q11.2 locus containing most proteins expressed in mitochondria [19] show increased cytoplasmic 8-oxo-2-deoxyguanosine (suggesting mitochondrial DNA oxidation), reduced number of PV-immunoreactive interneurons, and weakened PNN in anterior cingulate cortex [15]

Colonic microbes can trigger NLRP6-mediated caspase-1 activation and IL-18 release, and SCFAs acting at GPR43 and GPR109A help maintain homeostatic IL-18 levels that prevent excessive intestinal and hepatic inflammation [36]

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

doi: 10.1038/s41598-017-15668-z 61 YeePPWeiYKimSYLuTChihSYLawsonCet al

292 : L1590L1597

Aquaporin-9 immunohistochemistry in varicocele testes as a consequence of hypoxia in the sperm production site