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Song, J., Kwon, O., Chen, S., Daruwala, R., Eck, P., Park, J.B., Levine, M

FRV-1 targets ETC-I, inducing ROS and mitochondrial dysfunction in NQO1-negative cells but is inactivated in NQO1-positive MCF7 cells

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Thus, in human endothelial cells, we found that adhesion molecules, such as vascular adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1), are upregulated by the absence of GPx1 and the expression of adhesion molecules is further augmented with exposure to TNF or lipopolysaccharide