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Furthermore, Del Negro and Chandler revealed that PICs are central to sustaining excitability in the Vmes, with Na + -PICs and Ca 2+ -PICs forming the basis for rhythmic firing ( + channels and delayed rectifier K + channels are also essential for setting firing thresholds and recovery dynamics, thereby refining motor control and preventing malfunction

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Symptoms of vitamin B12, or folate, deficiency can include fatigue, lethargy, low mood, shortness of breath, and nerve problems