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Genetic variations in VDBP/( CYP2R1 ) are known to influence 25(OH)VD blood levels in response to VD supplementation (13, 19, 23, 29, 30, 52)

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130 Comparatively, the deficiency of ZIP8 has a substantial impact on zinc influx in effector T cells and results in reduced TCR-mediated signaling, including NF-B and MAPK signaling, which are involved in the differentiation of T helper (Th)17 cells
