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Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

doi: 10.1037/a0035661, 44

doi: 10.1089/ars.2011.4055 88 AshtonKHooperLHarveyLJHurstRCasgrainAFairweather-TaitSJ

doi: 10.1021/js970018g

mITT, Modified intention-to-treat analysis

(2022) The solute carrier MFSD1 decreases 1 Integrins activation status and thus metastasis