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Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results

Curr Pharm Des

PMC 1163421

N Engl J Med 1995

Both total iron content, which elevated in the RH group (1.2 0.03 g/mg prot), and Fe 2+ levels (0.3 0.02 mol/mg prot) were significantly decreased by DFP treatment to 0.9 0.09 g/mg prot ( P = 0.0068

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