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In line with our observations of MFN2 accumulation in the ER of primary cells following CER 16:0 exposure, WB revealed increased MFN2 content in ER of PE placentae relative to PTC (Fig

Due to the rapid proliferation of GBM, the TME is suppressed by factors such as acidity and hypoxia, rendering immunotherapy ineffective [95, 96]

Active mTORC1 phosphorylates downstream effectors including p70S6K and 4E-BP1, which together increase ribosomal biogenesis, enhance mRNA translation, and drive protein synthesis - the fundamental process underlying muscle hypertrophy and tissue regeneration

PMID 34417165

However, more research is needed to determine the efficacy and safety of NMD14 for the treatment of hematologic malignancies

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