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The NADH produced in the cytosol by ADH must be reduced back to NAD + via either the malate-aspartate shuttle or the glycerol-phosphate shuttle

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For instance, administration of FMT from ESKD patients to renal injured germ-free mice or antibiotic-treated rats resulted in an increased production of serum uraemic toxins, exacerbated renal fibrosis and oxidative stress, while control models with FMTs from healthy donors did not show these effects (Wang et al., 2020)
