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In recent years it has come to be used in cosmetic medicine as a technique for facial rejuvenation and for the treatment of alopecia or areas of hyperpigmentation.2 Lipolytic mesotherapy uses various agents with lipolytic activity (mainly phosphatidylcholine and deoxycholate) for the treatment of localized fat deposits in the neck, eyelids, hips, abdomen, or thighs.3 These substances act as detergents, provoking nonspecific damage to the cell wall, with adipocyte necrosis and subsequent inflammatory infiltrate with a predominance initially of neutrophils and later of T lymphocytes, with granulomas and foam cells.4 The final stage is secondary fibrosis in the adipose tissue.5 Although mesotherapy is considered a safe procedure as it is minimally invasive and is usually well tolerated, numerous local and systemic side effects have been reported

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For example, a high concentration of albumin, plasminogen, and prothrombin in the brain can initiate muscle cramp, glial activation or neuroinflammation [57]

All measures of brain function proved to have substantial improvements in one study that evaluated patients with alcohol addiction

Although L-Carnitine may help with weight loss in some people, it works best when combined with exercise and a balanced diet

Clin Neurol Neurosurg 115(Suppl 1):S86-89 [DOI] [PubMed] [Google Scholar] 71.Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG (2020) Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)