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Receptor Structure and Activation The IGF-1 receptor shares significant structural homology with the insulin receptor, existing as a heterotetrameric complex of two extracellular -subunits (which contain the ligand binding sites) and two transmembrane -subunits (which possess intrinsic tyrosine kinase activity in their intracellular domains)

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2A), while the A plaques appeared in both cortex and hippocampus of APP/PS1 mice after 8-week ethanol exposure (Fig

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J Clin Invest 121:42104221