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Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies

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For example, ascorbic acid may interact with iron and copper, reducing Fe 3+ to Fe (or Cu 2+ to Cu + ), which subsequently catalyzes the conversion of HO into hydroxyl radicals highly reactive species that can damage DNA

In vitro studies have also indicated that riboflavin itself has an antioxidant nature, independent of its action as the GR coenzyme ( Reference Toyosaki and Mineshita 47 )

G., Herning M., Petersen P., et al