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B12 is a cofactor for the enzyme, methylmalonyl-CoA mutase, which transforms methylmalonyl-CoA into succinyl-CoA, which the body can directly use in the Krebs cycle to produce ATP

At 75mg daily, most protocols observe metabolic effects within 24 weeks

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They may also evaluate the safety of the home, monitor food and drink intake, and teach patients and caregivers about the plan of care and how to carry it out

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